According to a hadith of Imam Muslim graded authentic, Both Prophet Isa & Dajjal will appear right after the muslim conquest of Constantinople. Constantinople was conquered by the muslims more than 500 years ago and we are yet to see the return of any one of them.
As per the verses of the Quran, the religion(deen) was completed during the time of Prophet Muhammad(PBUH). So it is clear that there remains no major reason for a return of another Prophet.
2nd coming of Jesus though has no mention in the Quran, is stated in many hadiths. Yet studying those hadiths, one can find that most of those hadiths were narrated by Abu Huraira, a person very much influenced by Kaab Al ahbar, the borrower of jewish tradition to Islam(Israyeliat).
Jesus is predicted to kill the pigs, destroy the cross and abolish Jizya. Abolishing Jizya means non-muslims including the people of the book will be given a choice either to convert to Islam or to get killed, which will clearly violate the Quranic law of religious freedom.
At the end of the day, Return of Jesus and the emergence of Mahdi & Dajjal are topics that should not concern general muslims. In
my view, submiting to the will of God by living a true peaceful life and contributing to the growth of human society & civilizations are the ultimate purposes of a human being.